Unified Program Integrity Contractors (UPICs) are unlike other Medicare contractors. Lori Foley, Office Managing Principal, PYA, and Brenna Jenny, Partner, Sidley Austin LLP, discuss some of the basic responsibilities of UPICs, what differentiates UPIC audits from other CMS audits, how UPIC audits progress from probe to referral, recommendations for providers who receive a UPIC audit, whether UPICs are effective, and how providers can design robust compliance programs.